Learning Materials
Features
Discover
Long-term depression (LTD) is a long-lasting decrease in synaptic strength between neurons, which plays a critical role in learning, memory, and neural plasticity in the brain. Unlike short-term depression, LTD involves complex molecular processes, including the activation of NMDA receptors and protein phosphatases that lead to the removal of AMPA receptors from the synapse. Understanding LTD can provide insights into developmental disorders and neurological diseases, highlighting its importance in both physiological functions and pathological conditions.
Millions of flashcards designed to help you ace your studies
Sign up for freeWhat equation models synaptic weakening in LTD?
Which process is NOT involved in long-term depression?
What is a potential consequence of dysregulated LTD?
What is Long-Term Depression (LTD)?
How does LTD contribute to neural balance?
What is Long-term Depression (LTD) in neuroscience?
What is an example of LTD's role in learning?
Which mechanism is NOT involved in Long-term Depression?
What role does long-term depression (LTD) play in neurons?
How do reduced AMPA receptors affect synaptic strength?
Which pathway is involved in modulating excitatory signals during LTD?
What equation models synaptic weakening in LTD?
Which process is NOT involved in long-term depression?
What is a potential consequence of dysregulated LTD?
What is Long-Term Depression (LTD)?
How does LTD contribute to neural balance?
What is Long-term Depression (LTD) in neuroscience?
What is an example of LTD's role in learning?
Which mechanism is NOT involved in Long-term Depression?
What role does long-term depression (LTD) play in neurons?
How do reduced AMPA receptors affect synaptic strength?
Which pathway is involved in modulating excitatory signals during LTD?
Achieve better grades quicker with Premium
Geld-zurück-Garantie, wenn du durch die Prüfung fällst
Did you know that StudySmarter supports you beyond learning?
Review generated flashcards
Start learning or create your own AI flashcards
Team long-term depression Teachers
Long-term depression (LTD) is a concept in neuroscience, describing a lasting decrease in the effectiveness of synaptic transmission. It mostly occurs in the brain and involves the weakening of synapses, which are the connections between neurons. This neural process plays a significant role in synaptic plasticity, critical for learning and memory.
Long-term Depression (LTD): A process whereby synaptic transmission becomes weaker over time, usually due to prolonged low-frequency stimulation or specific patterns of neural activity. This weakening is important for brain function and neuronal communication.
Long-term depression is essential for maintaining the balance and flexibility of neural networks. It helps the brain regulate the strength of synaptic connections through mechanisms such as:
Consider a person learning to play the piano. Initially, many neural connections work inefficiently. As the person practices, LTD refines the connections related to finger movements, making them more streamlined and efficient. Over time, this refinement translates to smoother play.
LTD often works in conjunction with Long-Term Potentiation (LTP), which strengthens synapses, establishing a balance in synaptic plasticity.
In neuroscience, understanding Long-term Depression (LTD) is crucial to grasp how the brain adapts to experiences. LTD weakens synaptic connections, pivotal for learning, memory, and overall brain plasticity. It primarily affects neurons and synapses, which are the basic building blocks of the brain's communication system.
Long-term Depression (LTD): A lasting decrease in synaptic strength due to specific patterns of neural activity or prolonged low-frequency stimulation.
LTD involves several intricate biological processes. Key mechanisms include:
Imagine a scenario where a neural pathway repeatedly sends weak signals. Over time, LTD will de-emphasize this pathway, allowing resources to be allocated for stronger, more vital pathways.
To delve deeper, consider the mathematical modeling of LTD. For instance, the strength of a synapse can be described by the equation:
\[ \text{Change in synaptic strength} = -\theta \times \text{current strength} \times \text{stimulation frequency} \times \text{time interval} \]
Where \(-\theta\) represents a scaling factor that determines how rapidly synaptic weakening occurs in response to neural activity. This model helps in understanding how various factors can influence the rate and extent of LTD.
LTD is considered a counterpart to Long-Term Potentiation (LTP), which strengthens synapses, crucial for balancing neural plasticity.
Long-term depression (LTD) in neurons is critical for understanding synaptic plasticity. Synaptic plasticity is how neurons adjust their strength and efficiency, playing a vital role in memory and learning.
Neurons communicate through synapses, where neurotransmitters carry signals from one neuron to another. LTD causes these synapses to weaken, an essential function in neural circuits. This weakening can occur through:
For instance, if you are learning a new language, LTD works by refining synaptic connections. Incorrect or less-used connections become weaker, allowing dominant and efficient networks to support language acquisition.
Let's explore LTD at a molecular level. The process often involves:
| Process Step | Description |
| AMPA Receptor Internalization | Reduces synaptic strength by decreasing receptor presence on the neuron surface. |
| Calcium Signaling | Essential for triggering various intracellular pathways, including those leading to LTD. |
| Protein Phosphatases | Enzymes like PP1, which remove phosphate groups, altering neuronal structure and function. |
Interestingly, the balance maintained by LTD and its counterpart, Long-Term Potentiation (LTP), is crucial for preventing disorders like epilepsy, which is characterized by excessive neuronal activity.
The mechanisms underlying Long-term Depression (LTD) are complex and involve multiple biological processes that lead to the weakening of synapses. These mechanisms are essential for adapting neural circuits during experiences such as learning and memory. Understanding these processes can help you appreciate how the brain regulates synaptic strength.
LTD can be caused by various factors that influence synaptic transmission. Here are some significant causes:
For example, in sensory adaptation, repeated exposure to a sound might lead to LTD in the auditory pathway, reflecting decreased sensitivity. This process helps you become less responsive to non-critical stimuli over time.
A deeper look into signaling pathways reveals:
| Pathway | Role in LTD |
| Calcium/Calmodulin-dependent Protein Kinase (CaMK) | Regulates various downstream effects that can lead to receptor internalization. |
| Protein Phosphatase 2A (PP2A) | Dephosphorylates target proteins, reducing synaptic efficacy. |
| mGluR5 Pathway | Linked to plasticity changes and modulating excitatory signals. |
While LTD is a physiological process in the brain, it can be linked to symptoms when dysregulated. Understanding the symptoms associated with maladaptive LTD can help you recognize its broader impact:
LTD and Long-term Potentiation (LTP) need to be in balance to ensure efficient brain function. Disruption in this balance can lead to various neurological disorders.
Sign up for free to gain access to all our flashcards.
At StudySmarter, we have created a learning platform that serves millions of students. Meet the people who work hard to deliver fact based content as well as making sure it is verified.
Lily Hulatt is a Digital Content Specialist with over three years of experience in content strategy and curriculum design. She gained her PhD in English Literature from Durham University in 2022, taught in Durham University’s English Studies Department, and has contributed to a number of publications. Lily specialises in English Literature, English Language, History, and Philosophy.
Get to know Lily
Gabriel Freitas is an AI Engineer with a solid experience in software development, machine learning algorithms, and generative AI, including large language models’ (LLMs) applications. Graduated in Electrical Engineering at the University of São Paulo, he is currently pursuing an MSc in Computer Engineering at the University of Campinas, specializing in machine learning topics. Gabriel has a strong background in software engineering and has worked on projects involving computer vision, embedded AI, and LLM applications.
Get to know Gabriel
StudySmarter is a globally recognized educational technology company, offering a holistic learning platform designed for students of all ages and educational levels. Our platform provides learning support for a wide range of subjects, including STEM, Social Sciences, and Languages and also helps students to successfully master various tests and exams worldwide, such as GCSE, A Level, SAT, ACT, Abitur, and more. We offer an extensive library of learning materials, including interactive flashcards, comprehensive textbook solutions, and detailed explanations. The cutting-edge technology and tools we provide help students create their own learning materials. StudySmarter’s content is not only expert-verified but also regularly updated to ensure accuracy and relevance.
Learn moreSave explanations to your personalised space and access them anytime, anywhere!
Sign up with Email Sign up with AppleBy signing up, you agree to the Terms and Conditions and the Privacy Policy of StudySmarter.
Already have an account? Log in
Sign up to highlight and take notes. It’s 100% free.
Explanations 
Flashcards 
StudySmarter AI 
Notes 
Study Plans 
Study Sets 
Exams 
Find a job 
Student Deals 
Magazine 
Mobile App 
