What is the role of surfactant in respiratory function?
Surfactant reduces surface tension in the alveoli, preventing their collapse during exhalation and ensuring efficient gas exchange. It stabilizes alveolar size, improves lung compliance, and lowers the work of breathing, which is essential for maintaining proper respiratory function.
How does surfactant deficiency affect premature infants?
Surfactant deficiency in premature infants leads to respiratory distress syndrome by causing alveolar collapse, increased work of breathing, and impaired gas exchange. This deficiency disrupts lung function and is a major cause of morbidity and mortality in this population.
How is surfactant related to lung stability and compliance?
Surfactant reduces surface tension in the alveoli, preventing their collapse and enhancing lung stability. It increases lung compliance, allowing the lungs to expand more easily during inhalation, facilitating efficient gas exchange and reducing the work of breathing.
What are the components of pulmonary surfactant and how do they function?
Pulmonary surfactant is composed primarily of phospholipids, particularly dipalmitoylphosphatidylcholine (DPPC), and surfactant proteins (SP-A, SP-B, SP-C, and SP-D). These components reduce surface tension in the alveoli, preventing collapse during exhalation, facilitating gas exchange, and defending against respiratory infections.
How is pulmonary surfactant used in treating respiratory distress syndrome?
Pulmonary surfactant is administered exogenously to treat respiratory distress syndrome by reducing surface tension in the alveoli, preventing their collapse, and improving lung compliance and oxygenation. This therapy is crucial for premature infants whose lungs are deficient in natural surfactant.